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Structure-function correlates of vision loss in neuromyelitis optica spectrum disorders

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Item Type:Article
Title:Structure-function correlates of vision loss in neuromyelitis optica spectrum disorders
Creators Name:Gigengack, N.K. and Oertel, F.C. and Motamedi, S. and Bereuter, C. and Duchow, A. and Rust, R. and Bellmann‑Strobl, J. and Ruprecht, K. and Schmitz-Hübsch, T. and Paul, F. and Brandt, A.U. and Zimmermann, H.G.
Abstract:Optic neuritis (ON) in neuromyelitis optica spectrum disorders (NMOSD) regularly leads to more profound vision loss compared to multiple sclerosis (MS) and myelin-oligodendrocyte-glycoprotein-antibody associated disease (MOGAD). Here we investigate ON-related vision loss in NMOSD compared to MS and MOGAD in order to identify neuroaxonal and retinal contributors to visual dysfunction. In this retrospective study we included patients with aquaporin-4-antibody seropositive NMOSD (n = 28), MOGAD (n = 14), MS (n = 29) and controls (n = 14). We assessed optic nerve damage and fovea morphometry by optical coherence tomography. Visual function was assessed as high (HCVA) and low contrast visual acuity (LCVA), and visual fields' mean deviation (MD). In all diseases, lower visual function was associated with peripapillary retinal nerve fiber layer (pRNFL) and ganglion cell and inner plexiform layer (GCIP) thinning following a broken stick model, with pRNFL and GCIP cutoff point at ca. 60 µm. HCVA loss per µm pRNFL and GCIP thinning was stronger in NMOSD compared with MOGAD. Foveal inner rim volume contributed to MD and LCVA in NMOSD eyes, only. Together these data supports that visual dysfunction in NMOSD is associated with neuroaxonal damage beyond the effect seen in MS and MOGAD. A primary retinopathy, respectively Müller cell pathology, may contribute to this effect.
Keywords:Aquaporin 4, Aquaporins, Glycoproteins, Multiple Sclerosis, Neuromyelitis Optica, Optic Neuritis, Retrospective Studies, Optical Coherence Tomography, Vision Disorders
Source:Scientific Reports
Publisher:Nature Publishing Group
Page Range:17545
Date:20 October 2022
Official Publication:https://doi.org/10.1038/s41598-022-19848-4
PubMed:View item in PubMed

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