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The nuclear envelope as a chromatin organizer

Item Type:Review
Title:The nuclear envelope as a chromatin organizer
Creators Name:Zuleger, N. and Robson, M.I. and Schirmer, E.C.
Abstract:In the past 15 years our perception of nuclear envelope function has evolved perhaps nearly as much as the nuclear envelope itself evolved in the last 3 billion years. Historically viewed as little more than a diffusion barrier between the cytoplasm and the nucleoplasm, the nuclear envelope is now known to have roles in the cell cycle, cytoskeletal stability and cell migration, genome architecture, epigenetics, regulation of transcription, splicing, and DNA replication. Here we will review both what is known and what is speculated about the role of the nuclear envelope in genome organization, particularly with respect to the positioning and repositioning of genes and chromosomes within the nucleus during differentiation.
Keywords:Differentiation, Genome Organization, Interphase Chromosome Positioning, Gene Position, Gene Regulation, Lamina, Nuclear Periphery Interactions
Publisher:Taylor & Francis
Page Range:339-49
Date:25 October 2011
Additional Information:This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
Official Publication:https://doi.org/10.4161/nucl.2.5.17846
PubMed:View item in PubMed

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