![[feed]](/style/images/feed-icon-14x14.png){kind=icon}
|
PDF (Original Article)
- Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
3MB | |
|
PDF (Supplementary Material)
- Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
4MB |
| Item Type: | Article |
|---|---|
| Title: | The NEMP family supports metazoan fertility and nuclear envelope stiffness |
| Creators Name: | Tsatskis, Y. and Rosenfeld, R. and Pearson, J.D. and Boswell, C. and Qu, Y. and Kim, K. and Fabian, L. and Mohammad, A. and Wang, X. and Robson, M.I. and Krchma, K. and Wu, J. and Gonçalves, J. and Hodzic, D. and Wu, S. and Potter, D. and Pelletier, L. and Dunham, W.H. and Gingras, A.C. and Sun, Y. and Meng, J. and Godt, D. and Schedl, T. and Ciruna, B. and Choi, K. and Perry, J.R.B. and Bremner, R. and Schirmer, E.C. and Brill, J.A. and Jurisicova, A. and McNeill, H. |
| Abstract: | Human genome-wide association studies have linked single-nucleotide polymorphisms (SNPs) in NEMP1 (nuclear envelope membrane protein 1) with early menopause; however, it is unclear whether NEMP1 has any role in fertility. We show that whole-animal loss of NEMP1 homologs in Drosophila, Caenorhabditis elegans, zebrafish, and mice leads to sterility or early loss of fertility. Loss of Nemp leads to nuclear shaping defects, most prominently in the germ line. Biochemical, biophysical, and genetic studies reveal that NEMP proteins support the mechanical stiffness of the germline nuclear envelope via formation of a NEMP-EMERIN complex. These data indicate that the germline nuclear envelope has specialized mechanical properties and that NEMP proteins play essential and conserved roles in fertility. |
| Source: | Science Advances |
| ISSN: | 2375-2548 |
| Publisher: | American Association for the Advancement of Science |
| Volume: | 6 |
| Number: | 35 |
| Page Range: | eabb4591 |
| Date: | 28 August 2020 |
| Official Publication: | https://doi.org/10.1126/sciadv.abb4591 |
| PubMed: | View item in PubMed |
Repository Staff Only: item control page
Download Statistics
Download Statistics
