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| Item Type: | Article |
|---|---|
| Title: | Interplay of diverse adjuvants and nanoparticle presentation of native-like HIV-1 envelope trimers |
| Creators Name: | Sliepen, K. and Schermer, E. and Bontjer, I. and Burger, J.A. and Lévai, R.F. and Mundsperger, P. and Brouwer, P.J.M. and Tolazzi, M. and Farsang, A. and Katinger, D. and Moore, J.P. and Scarlatti, G. and Shattock, R.J. and Sattentau, Q.J. and Sanders, R.W. |
| Abstract: | The immunogenicity of HIV-1 envelope (Env) trimers is generally poor. We used the clinically relevant ConM SOSIP trimer to compare the ability of different adjuvants (squalene emulsion, ISCOMATRIX, GLA-LSQ, and MPLA liposomes) to support neutralizing antibody (NAb) responses in rabbits. The trimers were administered as free proteins or on nanoparticles. The rank order for the adjuvants was ISCOMATRIX > SE > GLA-LSQ ~ MPLA liposomes > no adjuvant. Stronger NAb responses were elicited when the ConM SOSIP trimers were presented on ferritin nanoparticles. We also found that the GLA-LSQ adjuvant induced an unexpectedly strong antibody response to the ferritin core of the nanoparticles. This "off-target" effect may have compromised its ability to induce the more desired antitrimer antibodies. In summary, both adjuvants and nanoparticle display can improve the magnitude of the antibody response to SOSIP trimers but the best combination of trimer presentation and adjuvant can only be identified experimentally. |
| Source: | NPJ Vaccines |
| ISSN: | 2059-0105 |
| Publisher: | Springer Nature |
| Volume: | 6 |
| Number: | 1 |
| Page Range: | 103 |
| Date: | 17 August 2021 |
| Additional Information: | Erratum in: NPJ Vaccines 6: 134. |
| Official Publication: | https://doi.org/10.1038/s41541-021-00364-x |
| PubMed: | View item in PubMed |
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