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Macrophages and HIV-1: an unhealthy constellation

Item Type:Review
Title:Macrophages and HIV-1: an unhealthy constellation
Creators Name:Sattentau, Q.J. and Stevenson, M.
Abstract:Lentiviruses have a long-documented association with macrophages. Abundant evidence exists for in vitro and, in a tissue-specific manner, in vivo infection of macrophages by the primate lentiviruses HIV-1 and SIV. However, macrophage contribution to aspects of HIV-1 and SIV pathogenesis, and their role in viral persistence in individuals on suppressive antiretroviral therapy, remains unclear. Here we discuss recent evidence implicating macrophages in HIV-1-mediated disease and highlight directions for further investigation.
Keywords:HIV-1, Macrophage, Reservoir, Pathogenesis
Source:Cell Host & Microbe
ISSN:1931-3128
Publisher:Elsevier / Cell Press
Volume:19
Number:3
Page Range:304-310
Date:9 March 2016
Additional Information:Copyright © 2016 Elsevier Inc. All rights reserved.
Official Publication:https://doi.org/10.1016/j.chom.2016.02.013
External Fulltext:View full text on PubMed Central
PubMed:View item in PubMed

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