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| Item Type: | Review |
|---|---|
| Title: | Envelope glycoprotein trimers as HIV-1 vaccine immunogens |
| Creators Name: | Sattentau, Q.J. |
| Abstract: | The HIV-1 envelope glycoprotein spike is the target of neutralizing antibody attack, and hence represents the only relevant viral antigen for antibody-based vaccine design. Various approaches have been attempted to recapitulate Env in membrane-anchored and soluble forms, and these will be discussed here in the context of recent successes and challenges still to be overcome. |
| Keywords: | HIV-1, Vaccine, Neutralizing Antibodies, Envelope Glycoproteins, Trimer |
| Source: | Vaccines |
| ISSN: | 2076-393X |
| Publisher: | MDPI |
| Volume: | 1 |
| Number: | 4 |
| Page Range: | 497-512 |
| Date: | 28 October 2013 |
| Official Publication: | https://doi.org/10.3390/vaccines1040497 |
| PubMed: | View item in PubMed |
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