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| Item Type: | Article |
|---|---|
| Title: | Macrophage infection via selective capture of HIV-1-infected CD4(+) T cells |
| Creators Name: | Baxter, A.E. and Russell, R.A. and Duncan, C.J.A. and Moore, M.D. and Willberg, C.B. and Pablos, J.L. and Finzi, A. and Kaufmann, D.E. and Ochsenbauer, C. and Kappes, J.C. and Groot, F. and Sattentau, Q.J. |
| Abstract: | Macrophages contribute to HIV-1 pathogenesis by forming a viral reservoir and mediating neurological disorders. Cell-free HIV-1 infection of macrophages is inefficient, in part due to low plasma membrane expression of viral entry receptors. We find that macrophages selectively capture and engulf HIV-1-infected CD4(+) T cells leading to efficient macrophage infection. Infected T cells, both healthy and dead or dying, were taken up through viral envelope glycoprotein-receptor-independent interactions, implying a mechanism distinct from conventional virological synapse formation. Macrophages infected by this cell-to-cell route were highly permissive for both CCR5-using macrophage-tropic and otherwise weakly macrophage-tropic transmitted/founder viruses but restrictive for nonmacrophage-tropic CXCR4-using virus. These results have implications for establishment of the macrophage reservoir and HIV-1 dissemination in vivo. |
| Keywords: | CD4-Positive T-Lymphocytes, Cell Line, HIV Infections, HIV Receptors, HIV-1, Macrophages, Viral Envelope Proteins, Viral Tropism |
| Source: | Cell Host & Microbe |
| ISSN: | 1934-6069 |
| Publisher: | Cell Press |
| Volume: | 16 |
| Number: | 6 |
| Page Range: | 711-721 |
| Date: | 10 December 2014 |
| Official Publication: | https://doi.org/10.1016/j.chom.2014.10.010 |
| PubMed: | View item in PubMed |
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