Immunogen design to focus the B-cell repertoire

Item Type:	Article
Title:	Immunogen design to focus the B-cell repertoire
Creators Name:	Sattentau, Q.J.
Abstract:	PURPOSE OF REVIEW: This review aims to bring together recent developments relevant to the design of HIV-1 envelope glycoprotein-based immunogens to elicit broadly neutralizing antibodies (bNAbs). RECENT FINDINGS: The combined use of structural biology and deep sequencing of antigen-specific B-cell lineages has allowed cross-sectional and longitudinal views of antibody evolution towards broad and potent neutralization of HIV-1. Recent advances in molecular modelling allied with protein and glycoprotein engineering have fuelled the design of new-generation viral envelope glycoproteins (Env)-based antigens. SUMMARY: Although proof-of-principle for vaccine elicitation of bNAbs to HIV-1 is still lacking, many of the conceptual hurdles are being addressed.
Keywords:	Affinity Maturation, B-cell Receptor, Broadly Neutralizing Antibody, HIV-1 Envelope Glycoproteins
Source:	Current Opinion in HIV and AIDS
ISSN:	1746-630X
Publisher:	Lippincott Williams & Wilkins
Volume:	9
Number:	3
Page Range:	217-223
Date:	May 2014
Official Publication:	https://doi.org/10.1097/coh.0000000000000054
PubMed:	View item in PubMed

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