Efficient HIV-1 transmission from macrophages to T cells across transient virological synapses

Item Type:	Article
Title:	Efficient HIV-1 transmission from macrophages to T cells across transient virological synapses
Creators Name:	Groot, F. and Welsch, S. and Sattentau, Q.J.
Abstract:	Macrophages are reservoirs of HIV-1 infection, proposed to transmit virus to CD4(+) T cells, the primary target of the virus. Here we report that human monocyte-derived macrophages (MDMs) rapidly spread HIV-1 to autologous CD4(+) T cells resulting in productive infection. Transmission takes place across transient adhesive contacts between T cells and MDMs, which have the features of a virological synapse including copolarization of CD4 on the T cell with HIV-1 Gag and Env on the macrophage. We propose that an infected MDM can infect at least one T cell every 6 hours. Since HIV-1-infected macrophages can survive for many weeks, these results highlight the central role played by macrophages in HIV-1 infection and pathogenesis.
Keywords:	HIV-1, Infections, Macrophages, Synapses, T-Lymphocytes, Virology, Viruses, HIV-1 Infection, Adhesives
Source:	Blood
ISSN:	0006-4971
Publisher:	American Society of Hematology
Volume:	111
Number:	9
Page Range:	4660-3
Date:	1 May 2008
Official Publication:	https://doi.org/10.1182/blood-2007-12-130070
PubMed:	View item in PubMed

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