Helmholtz Gemeinschaft


Framework and baseline examination of the German National Cohort (NAKO)

PDF (Original Article) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
[img] Other (Supplementary Information)

Item Type:Article
Title:Framework and baseline examination of the German National Cohort (NAKO)
Creators Name:Peters, A. and Peters, A. and Greiser, K.H. and Göttlicher, S. and Ahrens, W. and Albrecht, M. and Bamberg, F. and Bärnighausen, T. and Becher, H. and Berger, K. and Beule, A. and Boeing, H. and Bohn, B. and Bohnert, K. and Braun, B. and Brenner, H. and Bülow, R. and Castell, S. and Damms-Machado, A. and Dörr, M. and Ebert, N. and Ecker, M. and Emmel, C. and Fischer, B. and Franzke, C.W. and Gastell, S. and Giani, G. and Günther, M. and Günther, K. and Günther, K.P. and Haerting, J. and Haug, U. and Heid, I.M. and Heier, M. and Heinemeyer, D. and Hendel, T. and Herbolsheimer, F. and Hirsch, J. and Hoffmann, W. and Holleczek, B. and Hölling, H. and Hörlein, A. and Jöckel, K.H. and Kaaks, R. and Karch, A. and Karrasch, S. and Kartschmit, N. and Kauczor, H.U. and Keil, T. and Kemmling, Y. and Klee, B. and Klüppelholz, B. and Kluttig, A. and Kofink, L. and Köttgen, A. and Kraft, D. and Krause, G. and Kretz, L. and Krist, L. and Kühnisch, J. and Kuß, O. and Legath, N. and Lehnich, A.T. and Leitzmann, M. and Lieb, W. and Linseisen, J. and Loeffler, M. and Macdonald, A. and Maier-Hein, K.H. and Mangold, N. and Meinke-Franze, C. and Meisinger, C. and Melzer, J. and Mergarten, B. and Michels, K.B. and Mikolajczyk, R. and Moebus, S. and Mueller, U. and Nauck, M. and Niendorf, T. and Nikolaou, K. and Obi, N. and Ostrzinski, S. and Panreck, L. and Pigeot, I. and Pischon, T. and Pschibul-Thamm, I. and Rathmann, W. and Reineke, A. and Roloff, S. and Rujescu, D. and Rupf, S. and Sander, O. and Schikowski, T. and Schipf, S. and Schirmacher, P. and Schlett, C.L. and Schmidt, B. and Schmidt, G. and Schmidt, M. and Schöne, G. and Schulz, H. and Schulze, M.B. and Schweig, A. and Sedlmeier, A.M. and Selder, S. and Six-Merker, J. and Sowade, R. and Stang, A. and Stegle, O. and Steindorf, K. and Stübs, G. and Swart, E. and Teismann, H. and Thiele, I. and Thierry, S. and Ueffing, M. and Völzke, H. and Waniek, S. and Weber, A. and Werner, N. and Wichmann, H.E. and Willich, S.N. and Wirkner, K. and Wolf, K. and Wolff, R. and Zeeb, H. and Zinkhan, M. and Zschocke, J.
Abstract:The German National Cohort (NAKO) is a multidisciplinary, population-based prospective cohort study that aims to investigate the causes of widespread diseases, identify risk factors and improve early detection and prevention of disease. Specifically, NAKO is designed to identify novel and better characterize established risk and protection factors for the development of cardiovascular diseases, cancer, diabetes, neurodegenerative and psychiatric diseases, musculoskeletal diseases, respiratory and infectious diseases in a random sample of the general population. Between 2014 and 2019, a total of 205,415 men and women aged 19-74 years were recruited and examined in 18 study centres in Germany. The baseline assessment included a face-to-face interview, self-administered questionnaires and a wide range of biomedical examinations. Biomaterials were collected from all participants including serum, EDTA plasma, buffy coats, RNA and erythrocytes, urine, saliva, nasal swabs and stool. In 56,971 participants, an intensified examination programme was implemented. Whole-body 3T magnetic resonance imaging was performed in 30,861 participants on dedicated scanners. NAKO collects follow-up information on incident diseases through a combination of active follow-up using self-report via written questionnaires at 2-3 year intervals and passive follow-up via record linkages. All study participants are invited for re-examinations at the study centres in 4-5 year intervals. Thereby, longitudinal information on changes in risk factor profiles and in vascular, cardiac, metabolic, neurocognitive, pulmonary and sensory function is collected. NAKO is a major resource for population-based epidemiology to identify new and tailored strategies for early detection, prediction, prevention and treatment of major diseases for the next 30 years.
Keywords:Population-Based Cohort, Non-Communicable Diseases, Communicable Diseases, Epidemiology, Life-Style And Socio-Economic Factors, Magnetic Resonance Imaging, Pre-Clinical Disease, Functional Impairments, Psychosocial Factors
Source:European Journal of Epidemiology
Page Range:1107-1124
Date:October 2022
Official Publication:https://doi.org/10.1007/s10654-022-00890-5
PubMed:View item in PubMed

Repository Staff Only: item control page


Downloads per month over past year

Open Access
MDC Library