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An interdisciplinary approach to characterize peanut-allergic patients - first data from the FOOD@ consortium

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Item Type:Article
Title:An interdisciplinary approach to characterize peanut-allergic patients - first data from the FOOD@ consortium
Creators Name:Worm, M. and Alexiou, A. and Höfer, V. and Birkner, T. and Jeanrenaud, A.C.S.N. and Fauchère, F. and Pazur, K. and Steinert, C. and Arnau-Soler, A. and Banerjee, P. and Diefenbach, A. and Dobbertin-Welsch, J. and Dölle-Bierke, S. and Francuzik, W. and Ghauri, A. and Heller, S. and Kalb, B. and Löber, U. and Marenholz, I. and Markó, L. and Scheffel, J. and Potapenko, O. and Roll, St. and Lau, S. and Lee, Y.A. and Braun, J. and Thiel, A. and Babina, M. and Altrichter, S. and Forslund, S.K. and Beyer, K.
Abstract:BACKGROUND: Peanut allergy is a frequent cause of food allergy and potentially life-threatening. Within this interdisciplinary research approach, we aim to unravel the complex mechanisms of peanut allergy. As a first step were applied in an exploratory manner the analysis of peanut allergic versus non-allergic controls. METHODS: Biosamples were studied regarding DNA methylation signatures, gut microbiome, adaptive and innate immune cell populations, soluble signaling molecules and allergen-reactive antibody specificities. We applied a scalable systems medicine computational workflow to the assembled data. RESULTS: We identified combined cellular and soluble biomarker signatures that stratify donors into peanut-allergic and non-allergic with high specificity. DNA methylation profiling revealed various genes of interest and stool microbiota differences in bacteria abundances. CONCLUSION: By extending our findings to a larger set of patients (e.g., children vs. adults), we will establish predictors for food allergy and tolerance and translate these as for example, indicators for interventional studies.
Keywords:Biomarker, Epigenetics, Food Allergy, Microbiome, Peanut Allergy
Source:Clinical and Translational Allergy
Page Range:e12197
Date:October 2022
Official Publication:https://doi.org/10.1002/clt2.12197
PubMed:View item in PubMed

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