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Organoids as tools for fundamental discovery and translation - a Keystone Symposia report

Item Type:Article
Title:Organoids as tools for fundamental discovery and translation - a Keystone Symposia report
Creators Name:Cable, J. and Lutolf, M.P. and Fu, J. and Park, S.E. and Apostolou, A. and Chen, S. and Song, C.J. and Spence, J.R. and Liberali, P. and Lancaster, M. and Meier, A.B. and Pek, N.M.Q. and Wells, J.M. and Capeling, M.M. and Uzquiano, A. and Musah, S. and Huch, M. and Gouti, M. and Hombrink, P. and Quadrato, G. and Urenda, J.P.
Abstract:Complex three-dimensional in vitro organ-like models, or organoids, offer a unique biological tool with distinct advantages over two-dimensional cell culture systems, which can be too simplistic, and animal models, which can be too complex and may fail to recapitulate human physiology and pathology. Significant progress has been made in driving stem cells to differentiate into different organoid types, though several challenges remain. For example, many organoid models suffer from high heterogeneity, and it can be difficult to fully incorporate the complexity of in vivo tissue and organ development to faithfully reproduce human biology. Successfully addressing such limitations would increase the viability of organoids as models for drug development and preclinical testing. On April 3-6, 2022, experts in organoid development and biology convened at the Keystone Symposium "Organoids as Tools for Fundamental Discovery and Translation" to discuss recent advances and insights from this relatively new model system into human development and disease.
Keywords:Development, Differentiation, Inflammatory Bowel Disease, Kidney Disease, Microfluidics, Organoids, Single-Cell Sequencing, Animals
Source:Annals of the New York Academy of Sciences
Publisher:New York Academy of Sciences
Page Range:196-208
Date:December 2022
Official Publication:https://doi.org/10.1111/nyas.14874
PubMed:View item in PubMed

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