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Impact of intravenous fish oil on omega-3 fatty acids and their derived lipid metabolites in patients with parenteral nutrition

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Item Type:Article
Title:Impact of intravenous fish oil on omega-3 fatty acids and their derived lipid metabolites in patients with parenteral nutrition
Creators Name:Weylandt, K.H. and Karber, M. and Xiao, Y. and Zhang, I.W. and Pevny, S. and Blüthner, E. and von Schacky, C. and Rothe, M. and Schunck, W.H. and Pape, U.F.
Abstract:BACKGROUND: Long-term parenteral nutrition (PN) can lead to intestinal failure-associated liver disease (IFALD). Omega-3 polyunsaturated fatty acids (n-3 PUFA) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) were shown to prevent IFALD. EPA- and DHA-derived oxylipins could contribute to this protective effect. METHODS: We analyzed the effect of parenteral fish oil on oxylipins in patients with chronic intestinal failure on PN (n=8). Patients first received no fish oil for 8 weeks and were then switched to a PN with 25% of fats as fish oil for another 8 weeks. Fatty acid (FA) profiles of red blood cells, PUFA-derived oxylipins generated by cyclooxygenase (COX), lipoxygenase (LOX) and cytochrome P450 (CYP) pathways, inflammatory markers and liver function were assessed before and during fish oil PN. RESULTS: EPA + DHA in erythrocytes (the Omega-3 Index) was high with a median of 11.96% at baseline and decreased to 9.57% without fish oil in the PN. Addition of fish oil in the PN increased the median Omega-3-Index to 12.75%. EPA- and DHA-derived CYP- and LOX-dependent metabolites increased significantly with fish oil in the PN, with less pronounced changes in arachidonic acid and its oxylipins. There were no significant changes of inflammation and liver function parameters. CONCLUSIONS: This study shows that fish oil-containing PN leads to primarily CYP and LOX-dependent n-3 PUFA derived inflammation dampening oxylipins (n-3 IDOs) arising from EPA and DHA. Within this short (16 week) study there were no significant changes in inflammation and clinical readout parameters.
Keywords:Omega-3 Polyunsaturated Fatty Acids, Cytochrome P450, Parenteral, Nutrition-Associated Liver Disease, Oxylipins
Source:Journal of Parenteral and Enteral Nutrition
Page Range:287-300
Date:26 September 2022
Official Publication:https://doi.org/10.1002/jpen.2448
PubMed:View item in PubMed

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