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Serum glial fibrillary acidic protein correlates with retinal structural damage in aquaporin-4 antibody positive neuromyelitis optica spectrum disorder

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Item Type:Article
Title:Serum glial fibrillary acidic protein correlates with retinal structural damage in aquaporin-4 antibody positive neuromyelitis optica spectrum disorder
Creators Name:Lin, T.Y. and Schindler, P. and Grittner, U. and Oertel, F.C. and Lu, A. and Motamedi, S. and Yadav, S.K. and Duchow, A.S. and Jarius, S. and Kuhle, J. and Benkert, P. and Brandt, A.U. and Bellmann-Strobl, J. and Schmitz-Hübsch, T. and Paul, F. and Ruprecht, K. and Zimmermann, H.G.
Abstract:BACKGROUND: Aquaporin-4 immunoglobulin-G positive (AQP4-IgG+) neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune astrocytopathy associated with optic neuritis (ON). Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is an oligodendrocytopathy with similar phenotype. Serum glial fibrillary acidic protein (sGFAP), an astrocyte-derived protein, is associated with disease severity in AQP4-IgG+ NMOSD. Serum neurofilament light (sNfL) indicates neuroaxonal damage. The objective was to investigate the association of sGFAP and sNfL with subclinical afferent visual system damage in clinically stable AQP4-IgG+ NMOSD and MOGAD patients. METHODS: In this cross-sectional study, clinically stable patients with AQP4-IgG+ NMOSD (N=33) and MOGAD (N=16), as diseased controls, underwent sGFAP and sNfL measurements by single molecule array, retinal optical coherence tomography and visually evoked potentials. RESULTS: Higher sGFAP concentrations were associated with thinner ganglion cell-inner plexiform layer (ß(95% confidence interval (CI)) = -0.75(-1.23 to -0.27), p=0.007) and shallower fovea (average pit depth: ß(95%CI) = -0.59(-0.63 to -0.55), p=0.020) in NMOSD non-ON eyes. Participants with pathological P100 latency had higher sGFAP (median [interquartile range]: 131.32 [81.10–179.34] vs. 89.50 [53.46–121.91]pg/ml, p=0.024). In MOGAD, sGFAP was not associated with retinal structural or visual functional measures. CONCLUSIONS: The association of sGFAP with structural and functional markers of afferent visual system damage in absence of ON suggests that sGFAP may be a sensitive biomarker for chronic disease severity in clinically stable AQP4-IgG+ NMOSD.
Keywords:Aquaporin 4, Autoantibodies, Biomarkers, Cross-Sectional Studies, Glial Fibrillary Acidic Protein, Immunoglobulin G, Intermediate Filaments, Neuromyelitis Optica, Optic Neuritis, Retinal Diseases
Source:Multiple Sclerosis and Related Disorders
Page Range:104100
Date:November 2022
Additional Information:Copyright © 2022. This manuscript version is made available under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/ or send a letter to Creative Commons, PO Box 1866, Mountain View, CA 94042, USA.
Official Publication:https://doi.org/10.1016/j.msard.2022.104100
PubMed:View item in PubMed

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