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CTGF/CCN2 has a possible detrimental role in the inflammation and the remyelination failure in the early stages of multiple sclerosis

Item Type:Article
Title:CTGF/CCN2 has a possible detrimental role in the inflammation and the remyelination failure in the early stages of multiple sclerosis
Creators Name:Fuchs, L. and Mausner-Fainberg, K. and Luban, A. and Asseyer, S.E. and Golan, M. and Benhamou, M. and Volovitz, I. and Regev, K. and Vigiser, I. and Piura, Y. and Kolb, H. and Paul, F. and Karni, A.
Abstract:Connective tissue growth factor (CTGF/CCN2) is a proinflammatory and an oligodendrocyte-differentiating blocking agent. It is found in MS lesions, which raises the possibility of involvement in MS pathogenesis. We found that its CSF and serum levels were higher in RR-MS patients than in controls and for serum compared to PP and SP-MS. Immune cells of both RR-MS and controls secreted CTGF/CCN2, which was enhanced by CD3/CD28 stimulation or by LPS. Anti-CTGF treatment of mice with experimental autoimmune encephalitis ameliorated its clinical severity. CTGF/CCN2 may play a role in the immune pathogenesis of MS and in remyelination failure in early stages of MS.
Keywords:Connective Tissue Growth Factor, Inflammation, Multiple Sclerosis, Remyelination, Animals, Mice
Source:Journal of Neuroimmunology
ISSN:0165-5728
Publisher:Elsevier
Volume:371
Page Range:577936
Date:15 October 2022
Official Publication:https://doi.org/10.1016/j.jneuroim.2022.577936
PubMed:View item in PubMed

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