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| Item Type: | Review |
|---|---|
| Title: | Evolution of the immune system in humans from infancy to old age |
| Creators Name: | Simon, A.K. and Hollander, G.A. and McMichael, A. |
| Abstract: | This article reviews the development of the immune response through neonatal, infant and adult life, including pregnancy, ending with the decline in old age. A picture emerges of a child born with an immature, innate and adaptive immune system, which matures and acquires memory as he or she grows. It then goes into decline in old age. These changes are considered alongside the risks of different types of infection, autoimmune disease and malignancy. |
| Keywords: | Adaptive Immunity, Innate Immunity, Infections |
| Source: | Proceedings of the Royal Society of London Series B-Biological Sciences |
| ISSN: | 0962-8452 |
| Publisher: | Royal Society |
| Volume: | 282 |
| Number: | 1821 |
| Page Range: | 20143085 |
| Date: | 22 December 2015 |
| Official Publication: | https://doi.org/10.1098/rspb.2014.3085 |
| PubMed: | View item in PubMed |
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