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Autophagy controls acquisition of aging features in macrophages

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Item Type:Article
Title:Autophagy controls acquisition of aging features in macrophages
Creators Name:Stranks, A.J. and Hansen, A.L. and Panse, I. and Mortensen, M. and Ferguson, D.J.P. and Puleston, D.J. and Shenderov, K. and Watson, A.S. and Veldhoen, M. and Phadwal, K. and Cerundolo, V. and Simon, A.K.
Abstract:Macrophages provide a bridge linking innate and adaptive immunity. An increased frequency of macrophages and other myeloid cells paired with excessive cytokine production is commonly seen in the aging immune system, known as ‘inflamm-aging'. It is presently unclear how healthy macrophages are maintained throughout life and what connects inflammation with myeloid dysfunction during aging. Autophagy, an intracellular degradation mechanism, has known links with aging and lifespan extension. Here, we show for the first time that autophagy regulates the acquisition of major aging features in macrophages. In the absence of the essential autophagy gene Atg7, macrophage populations are increased and key functions such as phagocytosis and nitrite burst are reduced, while the inflammatory cytokine response is significantly increased - a phenotype also observed in aged macrophages. Furthermore, reduced autophagy decreases surface antigen expression and skews macrophage metabolism toward glycolysis. We show that macrophages from aged mice exhibit significantly reduced autophagic flux compared to young mice. These data demonstrate that autophagy plays a critical role in the maintenance of macrophage homeostasis and function, regulating inflammation and metabolism and thereby preventing immunosenescence. Thus, autophagy modulation may prevent excess inflammation and preserve macrophage function during aging, improving immune responses and reducing the morbidity and mortality associated with inflamm-aging.
Keywords:Autophagy, Macrophages, Aging, Inflamm-aging, Inflammation, Metabolism, Animals, Mice
Source:Journal of Innate Immunity
ISSN:1662-811X
Publisher:Karger
Volume:7
Number:4
Page Range:375-391
Date:June 2015
Official Publication:https://doi.org/10.1159/000370112
PubMed:View item in PubMed

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