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Molecular definitions of autophagy and related processes

Item Type:Review
Title:Molecular definitions of autophagy and related processes
Creators Name:Galluzzi, L. and Baehrecke, E.H. and Ballabio, A. and Boya, P. and Bravo-San Pedro, J.M. and Cecconi, F. and Choi, A.M. and Chu, C.T. and Codogno, P. and Colombo, M.I. and Cuervo, A.M. and Debnath, J. and Deretic, V. and Dikic, I. and Eskelinen, E.L. and Fimia, G.M. and Fulda, S. and Gewirtz, D.A. and Green, D.R. and Hansen, M. and Harper, J.W. and Jäättelä, M. and Johansen, T. and Juhasz, G. and Kimmelman, A.C. and Kraft, C. and Ktistakis, N.T. and Kumar, S. and Levine, B. and Lopez-Otin, C. and Madeo, F. and Martens, S. and Martinez, J. and Melendez, A. and Mizushima, N. and Münz, C. and Murphy, L.O. and Penninger, J.M. and Piacentini, M. and Reggiori, F. and Rubinsztein, D.C. and Ryan, K.M. and Santambrogio, L. and Scorrano, L. and Simon, A.K. and Simon, H.U. and Simonsen, A. and Tavernarakis, N. and Tooze, S.A. and Yoshimori, T. and Yuan, J. and Yue, Z. and Zhong, Q. and Kroemer, G.
Abstract:Over the past two decades, the molecular machinery that underlies autophagic responses has been characterized with ever increasing precision in multiple model organisms. Moreover, it has become clear that autophagy and autophagy-related processes have profound implications for human pathophysiology. However, considerable confusion persists about the use of appropriate terms to indicate specific types of autophagy and some components of the autophagy machinery, which may have detrimental effects on the expansion of the field. Driven by the overt recognition of such a potential obstacle, a panel of leading experts in the field attempts here to define several autophagy-related terms based on specific biochemical features. The ultimate objective of this collaborative exchange is to formulate recommendations that facilitate the dissemination of knowledge within and outside the field of autophagy research.
Keywords:Chaperone-Mediated Autophagy, LC3-associated Phagocytosis, Microautophagy, Mitophagy, Xenophagy, Animals, Mice
Source:EMBO Journal
Publisher:EMBO Press / Wiley
Page Range:1811-1836
Date:3 July 2017
Official Publication:https://doi.org/10.15252/embj.201796697
PubMed:View item in PubMed

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