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Mechanistic roles of autophagy in hematopoietic differentiation

Item Type:Review
Title:Mechanistic roles of autophagy in hematopoietic differentiation
Creators Name:Riffelmacher, T. and Simon, A.K.
Abstract:Autophagy is increasingly recognized for its active role in development and differentiation. In particular, its role in the differentiation of hematopoietic cells has been extensively studied, likely because blood cells are accessible, easy to identify and purify, and their progenitor tree is well defined. This review aims to discuss the mechanisms by which autophagy impacts on differentiation, using hematopoietic cell types as examples. Autophagy's roles include the remodeling during terminal differentiation, the maintenance of a long-lived cell type, and the regulation of the balance between self-renewal and quiescence in stem-like cells. We discuss and compare the mechanistic roles of autophagy, such as prevention of apoptosis, supply of energy metabolites and metabolic adaption, and selective degradation of organelles and of regulatory factors.
Keywords:Autophagy, Differentiation, Hematopoiesis, Hematopoietic Stem Cell, Lineage Commitment, Animals
Source:FEBS Journal
Page Range:1008-1020
Date:April 2017
Official Publication:https://doi.org/10.1111/febs.13962
PubMed:View item in PubMed

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