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Ferritin trajectories over repeated whole blood donations: results from the FIND+ study

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Item Type:Article
Title:Ferritin trajectories over repeated whole blood donations: results from the FIND+ study
Creators Name:Moazzen, S. and Sweegers, M.G. and Janssen, M. and Hogema, B.M. and Hoekstra, T. and Van den Hurk, K.
Abstract:BACKGROUND: Depending on post-donation erythropoiesis, available iron stores, and iron absorption rates, optimal donation intervals may differ between donors. This project aims to define subpopulations of donors with different ferritin trajectories over repeated donations. METHODS: Ferritin levels of 300 new whole blood donors were measured from stored (lookback) samples from each donation over two years in an observational cohort study. Latent classes of ferritin level trajectories were investigated separately using growth mixture models for male and female donors. General linear mixed models assessed associations of ferritin levels with subsequent iron deficiency and/or low hemoglobin. RESULTS: Two groups of donors were identified using group-based trajectory modeling in both genders. Ferritin levels showed rather linear reductions among 42.9% of male donors and 87.7% of female donors. For the remaining groups of donors, steeper declines in ferritin levels were observed. Ferritin levels at baseline and the end of follow-up varied greatly between groups. CONCLUSIONS: Repeated ferritin measurements show depleting iron stores in all-new whole blood donors, the level at which mainly depends on baseline ferritin levels. Tailored, less intensive donation strategies might help to prevent low iron in donors, and could be supported with ferritin monitoring and/or iron supplementation.
Keywords:Ferritins, Blood, Blood Donors
Source:Journal of Clinical Medicine
Page Range:3581
Date:1 July 2022
Official Publication:https://doi.org/10.3390/jcm11133581
PubMed:View item in PubMed

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