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Role of Gpnmb in atherosclerosis of female mice

Item Type:Article
Title:Role of Gpnmb in atherosclerosis of female mice
Creators Name:Nickl, B. and Qadri, F. and Bader, M.
Abstract:Atherosclerosis has become prevalent not only in Western industrialized countries but all over the globe. Gpnmb, a transmembrane protein expressed by macrophages, has been detected in aortic lesions. We created an ApoE/Gpnmb-double knockout mouse using Crispr-Cas9 to examine the effect of Gpnmb deficiency on the development of atherosclerotic plaques. Feeding female mice a high cholesterol diet for 8 and 12 weeks, we detected an increased plaque size in aortic root sections of Gpnmb-deficient compared to control mice. However, the plaque area in whole thoracic and abdominal aorta was not different. Despite its strong expression in macrophages in aortic plaques, Gpnmb exerts only a minor effect on the growth of the atherosclerotic plaques in female mice. Future studies should examine plaque stability and include both sexes to elucidate the sex-specific function of Gpnmb in atherosclerosis.
Keywords:Abdominal Aorta, Animal Disease Models, Apolipoproteins E, Atherosclerosis, Atherosclerotic Plaque, Eye Proteins, Inbred C57BL Mice, Knockout Mice, Macrophages, Membrane Glycoproteins, Animals, Mice
Source:Biochemical and Biophysical Research Communications
Page Range:20-24
Date:17 September 2022
Official Publication:https://doi.org/10.1016/j.bbrc.2022.06.082
PubMed:View item in PubMed

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