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Longitudinal retinal changes in MOGAD

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Item Type:Article
Title:Longitudinal retinal changes in MOGAD
Creators Name:Oertel, F.C. and Sotirchos, E.S. and Zimmermann, H.G. and Motamedi, S. and Specovius, S. and Asseyer, E.S. and Chien, C. and Cook, L. and Vasileiou, E. and Filippatou, A. and Calabresi, P.A. and Saidha, S. and Pandit, L. and D'Cunha, A. and Outteryck, O. and Zéphir, H. and Pittock, S. and Flanagan, E.P. and Bhatti, M.T. and Rommer, P.S. and Bsteh, G. and Zrzavy, T. and Kuempfel, T. and Aktas, O. and Ringelstein, M. and Albrecht, P. and Ayzenberg, I. and Pakeerathan, T. and Knier, B. and Aly, L. and Asgari, N. and Soelberg, K. and Marignier, R. and Tilikete, C.F. and Calvo, A.C. and Villoslada, P. and Sanchez-Dalmau, B. and Martinez-Lapiscina, E.H. and Llufriu, S. and Green, A.J. and Yeaman, M.R. and Smith, T.J. and Brandt, A.U. and Chen, J. and Paul, F. and Havla, J.
Abstract:OBJECTIVE: Patients with myelin oligodendrocyte glycoprotein antibody (MOG-IgG) associated disease (MOGAD) suffer from severe optic neuritis (ON) leading to retinal neuro-axonal loss, which can be quantified by optical coherence tomography (OCT). We assessed whether ON-independent retinal atrophy can be detected in MOGAD. METHODS: Eighty MOGAD patients and 139 healthy controls (HC) were included. OCT data was acquired with 1) Spectralis spectral domain OCT (MOGAD (N=66) and HC (N=103)) and 2) Cirrus HD-OCT (MOGAD (N=14) and HC (N=36)). Macular combined ganglion cell and inner plexiform layer (GCIPL) and peripapillary retinal nerve fibre layer (pRNFL) were quantified. RESULTS: At baseline, GCIPL and pRNFL were lower in MOGAD eyes with a history of ON (MOGAD-ON) compared with MOGAD eyes without a history of ON (MOGAD-NON) and HC (p<0.001). MOGAD-NON eyes had lower GCIPL volume compared to HC (p<0.001) in the Spectralis, but not in the Cirrus cohort. Longitudinally (follow-up up to 3 years), MOGAD-ON with ON within the last 6-12 months before baseline exhibited greater pRNFL thinning than MOGAD-ON with an ON >12 months ago (p<0.001). The overall MOGAD cohort did not exhibit faster GCIPL thinning compared with HC. INTERPRETATION: Our study suggests the absence of attack-independent retinal damage in MOGAD. Yet, ongoing neuroaxonal damage or oedema resolution seems to occur for up to 12 months after ON, which is longer than what has been reported with other ON forms. These findings support that the pathomechanisms underlying optic nerve involvement and the evolution of OCT retinal changes after ON is distinct in MOGAD. This article is protected by copyright. All rights reserved.
Keywords:Optical Coherence Tomography, Optic Neuritis, Myelin Oligodendrocyte Glycoprotein
Source:Annals of Neurology
Page Range:476-485
Date:September 2022
Official Publication:https://doi.org/10.1002/ana.26440
PubMed:View item in PubMed

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