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Physiological functions of intracellular protein degradation

Item Type:Review
Title:Physiological functions of intracellular protein degradation
Creators Name:McShane, E. and Selbach, M.
Abstract:While cellular proteins were initially thought to be stable, research over the last decades has firmly established that intracellular protein degradation is an active and highly regulated process: Lysosomal, proteasomal, and mitochondrial degradation systems were identified and found to be involved in a staggering number of biological functions. Here, we provide a global overview of the diverse roles of cellular protein degradation using seven categories: homeostasis, regulation, quality control, stoichiometry control, proteome remodeling, immune surveillance, and baseline turnover. Using selected examples, we outline how proteins are degraded and why this is functionally relevant.
Keywords:Protein Degradation, Autophagy, Ubiquitin Proteasome System, Protein Quality Control
Source:Annual Review of Cell and Developmental Biology
Publisher:Annual Reviews
Page Range:241-262
Date:October 2022
Official Publication:https://doi.org/10.1146/annurev-cellbio-120420-091943
PubMed:View item in PubMed

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