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| Item Type: | Review |
|---|---|
| Title: | Wie Kochsalz Mitochondrien beeinflusst |
| Creators Name: | Geisberger, S. |
| Abstract: | Dietary high salt (HS) is a major risk factor for cardio-vascular and chronic inflammatory diseases. Sodium can increase postprandially but can also accumulate in diverse tissues. Immune cells, such as macrophages, sense this salty environment and adapt accordingly, shifting towards a more pro-inflammatory state. Mechanistically, HS inhibits complex II of the electron transport chain and thereby reduces mitochondrial function. In two independent clinical studies, an HS-diet transiently impaired human monocytic mitochondrial function. |
| Source: | BIOspektrum |
| ISSN: | 0947-0867 |
| Publisher: | Springer / Spektrum Akademischer Verlag |
| Volume: | 28 |
| Number: | 4 |
| Page Range: | 387-389 |
| Date: | June 2022 |
| Official Publication: | https://doi.org/10.1007/s12268-022-1781-y |
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