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| Item Type: | Article |
|---|---|
| Title: | Peripheral serotonin deficiency affects anxiety-like behavior and the molecular response to an acute challenge in rats |
| Creators Name: | Sbrini, G. and Hanswijk, S.I. and Brivio, P. and Middelman, A. and Bader, M. and Fumagalli, F. and Alenina, N. and Homberg, J.R. and Calabrese, F. |
| Abstract: | Serotonin is synthetized through the action of tryptophan hydroxylase (TPH) enzymes. While the TPH2 isoform is responsible for the production of serotonin in the brain, TPH1 is expressed in peripheral organs. Interestingly, despite its peripheral localization, alterations of the gene coding for TPH1 have been related to stress sensitivity and an increased susceptibility for psychiatric pathologies. On these bases, we took advantage of newly generated TPH1(-/-)rats, and we evaluated the impact of the lack of peripheral serotonin on the behavior and expression of brain plasticity-related genes under basal conditions and in response to stress. At a behavioral level, TPH1(-/-) rats displayed reduced anxiety-like behavior. Moreover, we found that neuronal activation, quantified by the expression of (Bdnf) and the immediate early gene (Arc) and transcription of glucocorticoid responsive genes after 1 h of acute restraint stress, was blunted in TPH1(-/-) rats in comparison to TPH1 animals(+/+). Overall, we provided evidence for the influence of peripheral serotonin levels in modulating brain functions under basal and dynamic situations. |
| Keywords: | Serotonin, Tryptophan Hydroxylase, Acute Stress, Restraint Stress, Bdnf, TPH1, Animals, Rats |
| Source: | International Journal of Molecular Sciences |
| ISSN: | 1422-0067 |
| Publisher: | MDPI |
| Volume: | 23 |
| Number: | 9 |
| Page Range: | 4941 |
| Date: | 29 April 2022 |
| Official Publication: | https://doi.org/10.3390/ijms23094941 |
| PubMed: | View item in PubMed |
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