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The physics of DNA folding: polymer models and phase-separation

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Item Type:Review
Title:The physics of DNA folding: polymer models and phase-separation
Creators Name:Esposito, A., Abraham, A., Conte, M., Vercellone, F., Prisco, A., Bianco, S. and Chiariello, A.M.
Abstract:Within cell nuclei, several biophysical processes occur in order to allow the correct activities of the genome such as transcription and gene regulation. To quantitatively investigate such processes, polymer physics models have been developed to unveil the molecular mechanisms underlying genome functions. Among these, phase-separation plays a key role since it controls gene activity and shapes chromatin spatial structure. In this paper, we review some recent experimental and theoretical progress in the field and show that polymer physics in synergy with numerical simulations can be helpful for several purposes, including the study of molecular condensates, gene-enhancer dynamics, and the three-dimensional reconstruction of real genomic regions.
Keywords:Phase-Separation, Chromatin Organization, Polymer Physics, Gene Regulation, Molecular Dynamics, Phase Transitions
Source:Polymers
ISSN:2073-4360
Publisher:MDPI
Volume:14
Number:9
Page Range:1918
Date:9 May 2022
Official Publication:https://doi.org/10.3390/polym14091918
PubMed:View item in PubMed

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