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Left ventricular remodelling post-myocardial infarction: pathophysiology, imaging, and novel therapies

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Item Type:Review
Title:Left ventricular remodelling post-myocardial infarction: pathophysiology, imaging, and novel therapies
Creators Name:Frantz, S. and Hundertmark, M.J. and Schulz-Menger, J. and Bengel, F.M. and Bauersachs, J.
Abstract:Most patients survive acute myocardial infarction (MI). Yet this encouraging development has certain drawbacks: heart failure (HF) prevalence is increasing and patients affected tend to have more comorbidities worsening economic strain on healthcare systems and impeding effective medical management. The heart's pathological changes in structure and/or function, termed myocardial remodelling, significantly impact on patient outcomes. Risk factors like diabetes, chronic obstructive pulmonary disease, female sex, and others distinctly shape disease progression on the 'road to HF'. Despite the availability of HF drugs that interact with general pathways involved in myocardial remodelling, targeted drugs remain absent, and patient risk stratification is poor. Hence, in this review, we highlight the pathophysiological basis, current diagnostic methods and available treatments for cardiac remodelling following MI. We further aim to provide a roadmap for developing improved risk stratification and novel medical and interventional therapies.
Keywords:Remodelling, Fibrosis, Heart Failure, Myocardial Infarction
Source:European Heart Journal
Publisher:Oxford University Press
Page Range:2549-2561
Date:14 July 2022
Official Publication:https://doi.org/10.1093/eurheartj/ehac223
PubMed:View item in PubMed

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