The role of intraspinal sensory neurons in the control of quadrupedal locomotion
| Item Type: | Article |
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| Title: | The role of intraspinal sensory neurons in the control of quadrupedal locomotion |
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| Creators Name: | Gerstmann, K. and Jurčić, N. and Blasco, E. and Kunz, S. and de Almeida Sassi, F. and Wanaverbecq, N. and Zampieri, N. |
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| Abstract: | From swimming to walking and flying, animals have evolved specific locomotor strategies to thrive in different habitats. All types of locomotion depend on the integration of motor commands and sensory information to generate precisely coordinated movements. Cerebrospinal-fluid-contacting neurons (CSF-cN) constitute a vertebrate sensory system that monitors CSF composition and flow. In fish, CSF-cN modulate swimming activity in response to changes in pH and bending of the spinal cord; however, their role in mammals remains unknown. We used mouse genetics to study their function in quadrupedal locomotion. We found that CSF-cN are directly integrated into spinal motor circuits. The perturbation of CSF-cN function does not affect general motor activity nor the generation of locomotor rhythm and pattern but results in specific defects in skilled movements. These results identify a role for mouse CSF-cN in adaptive motor control and indicate that this sensory system evolved a novel function to accommodate the biomechanical requirements of limb-based locomotion. |
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| Keywords: | CSF-Contacting Neurons, Spinal Circuits, Motor Control, Pkd2l1, Interoception, Sensorimotor Integration, Animals, Mice, Zebrafish |
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| Source: | Current Biology |
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| ISSN: | 0960-9822 |
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| Publisher: | Cell Press |
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| Volume: | 32 |
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| Number: | 11 |
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| Page Range: | 2442-2453 |
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| Date: | 6 June 2022 |
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| Additional Information: | Copyright © 2022 Elsevier Inc. This manuscript version is made available under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/ or send a letter to Creative Commons, PO Box 1866, Mountain View, CA 94042, USA. |
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| Official Publication: | https://doi.org/10.1016/j.cub.2022.04.019 |
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| PubMed: | View item in PubMed |
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| Related to: | |
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