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The role of intraspinal sensory neurons in the control of quadrupedal locomotion

Item Type:Article
Title:The role of intraspinal sensory neurons in the control of quadrupedal locomotion
Creators Name:Gerstmann, K. and Jurčić, N. and Blasco, E. and Kunz, S. and de Almeida Sassi, F. and Wanaverbecq, N. and Zampieri, N.
Abstract:From swimming to walking and flying, animals have evolved specific locomotor strategies to thrive in different habitats. All types of locomotion depend on the integration of motor commands and sensory information to generate precisely coordinated movements. Cerebrospinal-fluid-contacting neurons (CSF-cN) constitute a vertebrate sensory system that monitors CSF composition and flow. In fish, CSF-cN modulate swimming activity in response to changes in pH and bending of the spinal cord; however, their role in mammals remains unknown. We used mouse genetics to study their function in quadrupedal locomotion. We found that CSF-cN are directly integrated into spinal motor circuits. The perturbation of CSF-cN function does not affect general motor activity nor the generation of locomotor rhythm and pattern but results in specific defects in skilled movements. These results identify a role for mouse CSF-cN in adaptive motor control and indicate that this sensory system evolved a novel function to accommodate the biomechanical requirements of limb-based locomotion.
Keywords:CSF-Contacting Neurons, Spinal Circuits, Motor Control, Pkd2l1, Interoception, Sensorimotor Integration, Animals, Mice
Source:Current Biology
ISSN:0960-9822
Publisher:Cell Press
Date:4 May 2022
Official Publication:https://doi.org/10.1016/j.cub.2022.04.019
PubMed:View item in PubMed

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