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The blood-brain barrier-a metabolic ecosystem

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Item Type:Editorial
Title:The blood-brain barrier-a metabolic ecosystem
Creators Name:Castro, M. and Potente, M.
Abstract:A functional blood-brain barrier relies on a tightly controlled interplay between endothelial cells, pericytes, and astrocytes, which together form the neurovascular unit. Recent work by Lee et al (2022) discovers endothelial cell-derived lactate as a crucial metabolic fuel for brain pericytes, revealing a new way of CNS vascular communication that links nutrient metabolism to blood-brain barrier function.
Keywords:Astrocytes, Blood-Brain Barrier, Brain, Ecosystem, Endothelial Cells, Pericytes / Metabolism
Source:EMBO Journal
ISSN:0261-4189
Publisher:EMBO Press / Wiley
Volume:41
Number:9
Page Range:e111189
Date:2 May 2022
Additional Information:Copyright © 2022 The Authors
Official Publication:https://doi.org/10.15252/embj.2022111189
External Fulltext:View full text on PubMed Central
PubMed:View item in PubMed

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