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Time-keeping and decision-making in living cells: Part I

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Item Type:Editorial
Title:Time-keeping and decision-making in living cells: Part I
Creators Name:Tyson, J.J. and Csikasz-Nagy, A. and Gonze, D. and Kim, J.K. and Santos, S. and Wolf, J.
Abstract:To survive and reproduce, a cell must process information from its environment and its own internal state and respond accordingly, in terms of metabolic activity, gene expression, movement, growth, division and differentiation. These signal–response decisions are made by complex networks of interacting genes and proteins, which function as biochemical switches and clocks, and other recognizable information-processing circuitry. This theme issue of Interface Focus (in two parts) brings together articles on time-keeping and decision-making in living cells—work that uses precise mathematical modelling of underlying molecular regulatory networks to understand important features of cell physiology. Part I focuses on time-keeping: mechanisms and dynamics of biological oscillators and modes of synchronization and entrainment of oscillators, with special attention to circadian clocks.
Keywords:Molecular Regulatory Networks, Feedback Loops, Mathematical Modelling, Multi-Rhythmicity, Entrainment, Circadian Rhythms
Source:Interface Focus
Publisher:Royal Society of London
Page Range:20220011
Date:6 June 2022
Official Publication:https://doi.org/10.1098/rsfs.2022.0011

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