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Oxidative RNA damage in the pathogenesis and treatment of type 2 diabetes

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Item Type:Review
Title:Oxidative RNA damage in the pathogenesis and treatment of type 2 diabetes
Creators Name:Chen, X. and Yu, H. and Li, Z. and Ye, W. and Liu, Z. and Gao, J. and Wang, Y. and Li, X. and Zhang, L. and Alenina, N. and Bader, M. and Ding, H. and Li, P. and Aung, L.H.H.
Abstract:Excessive production of free radicals can induce cellular damage, which is associated with many diseases. RNA is more susceptible to oxidative damage than DNA due to its single-stranded structure, and lack of protective proteins. Yet, oxidative damage to RNAs received little attention. Accumulating evidence reveals that oxidized RNAs may be dysfunctional and play fundamental role in the occurrence and development of type 2 diabetes (T2D) and its complications. Oxidized guanine nucleoside, 8-oxo-7, 8-dihydroguanine (8-oxoGuo) is a biomarker of RNA oxidation that could be associated with prognosis in patients with T2D. Nowadays, some clinical trials used antioxidants for the treatment of T2D, though the pharmacological effects remained unclear. In this review, we overview the cellular handling mechanisms and the consequences of the oxidative RNA damage for the better understanding of pathogenesis of T2D and may provide new insights to better therapeutic strategy.
Keywords:Oxidative Damage, RNA Oxidation, 8-OxoGuo, Type 2 Diabetes, Therapeutic Strategy
Source:Frontiers in Physiology
Publisher:Frontiers Media SA
Page Range:725919
Date:28 March 2022
Official Publication:https://doi.org/10.3389/fphys.2022.725919
PubMed:View item in PubMed

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