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Autophagy in major human diseases

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Item Type:Review
Title:Autophagy in major human diseases
Creators Name:Klionsky, D.J. and Petroni, G. and Amaravadi, R.K. and Baehrecke, E.H. and Ballabio, A. and Boya, P. and Bravo-San Pedro, J.M. and Cadwell, K. and Cecconi, F. and Choi, A.M.K. and Choi, M.E. and Chu, C.T. and Codogno, P. and Colombo, M.I. and Cuervo, A.M. and Deretic, V. and Dikic, I. and Elazar, Z. and Eskelinen, E.L. and Fimia, G.M. and Gewirtz, D.A. and Green, D.R. and Hansen, M. and Jäättelä, M. and Johansen, T. and Juhász, G. and Karantza, V. and Kraft, C. and Kroemer, G. and Ktistakis, N.T. and Kumar, S. and Lopez-Otin, C. and Macleod, K.F. and Madeo, F. and Martinez, J. and Meléndez, A. and Mizushima, N. and Münz, C. and Penninger, J.M. and Perera, R.M. and Piacentini, M. and Reggiori, F. and Rubinsztein, D.C. and Ryan, K.M. and Sadoshima, J. and Santambrogio, L. and Scorrano, L. and Simon, H.U. and Simon, A.K. and Simonsen, A. and Stolz, A. and Tavernarakis, N. and Tooze, S.A. and Yoshimori, T. and Yuan, J. and Yue, Z. and Zhong, Q. and Galluzzi, L. and Pietrocola, F.
Abstract:Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease in a plethora of experimental models. Consistently, mutations in autophagy-related processes cause severe human pathologies. Here, we review and discuss preclinical data linking autophagy dysfunction to the pathogenesis of major human disorders including cancer as well as cardiovascular, neurodegenerative, metabolic, pulmonary, renal, infectious, musculoskeletal, and ocular disorders.
Keywords:Aging, Cancer, Inflammation, Metabolic Syndromes, Neurodegeneration, Animals
Source:EMBO Journal
ISSN:0261-4189
Publisher:EMBO Press
Volume:40
Number:19
Page Range:e108863
Date:1 October 2021
Official Publication:https://doi.org/10.15252/embj.2021108863
PubMed:View item in PubMed

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