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Autophagy in healthy aging and disease

Item Type:Review
Title:Autophagy in healthy aging and disease
Creators Name:Aman, Y. and Schmauck-Medina, T. and Hansen, M. and Morimoto, R.I. and Simon, A.K. and Bjedov, I. and Palikaras, K. and Simonsen, A. and Johansen, T. and Tavernarakis, N. and Rubinsztein, D.C. and Partridge, L. and Kroemer, G. and Labbadia, J. and Fang, E.F.
Abstract:Autophagy is a fundamental cellular process that eliminates molecules and subcellular elements, including nucleic acids, proteins, lipids and organelles, via lysosome-mediated degradation to promote homeostasis, differentiation, development and survival. While autophagy is intimately linked to health, the intricate relationship among autophagy, aging and disease remains unclear. This Review examines several emerging features of autophagy and postulates how they may be linked to aging as well as to the development and progression of disease. In addition, we discuss current preclinical evidence arguing for the use of autophagy modulators as suppressors of age-related pathologies such as neurodegenerative diseases. Finally, we highlight key questions and propose novel research avenues that will likely reveal new links between autophagy and the hallmarks of aging. Understanding the precise interplay between autophagy and the risk of age-related pathologies across organisms will eventually facilitate the development of clinical applications that promote long-term health.
Keywords:Ageing, Lysosomes, Macroautophagy, Neurological Disorders
Source:Nature Aging
Publisher:Nature Research
Page Range:634-650
Date:12 August 2021
Official Publication:https://doi.org/10.1038/s43587-021-00098-4
PubMed:View item in PubMed

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