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| Item Type: | Article |
|---|---|
| Title: | Asymmetric cell division shapes naive and virtual memory T-cell immunity during ageing |
| Creators Name: | Borsa, M. and Barandun, N. and Gräbnitz, F. and Barnstorf, I. and Baumann, N.S. and Pallmer, K. and Baumann, S. and Stark, D. and Balaz, M. and Oetiker, N. and Wagen, F. and Wolfrum, C. and Simon, A.K. and Joller, N. and Barral, Y. and Spörri, R. and Oxenius, A. |
| Abstract: | Efficient immune responses rely on heterogeneity, which in CD8(+) T cells, amongst other mechanisms, is achieved by asymmetric cell division (ACD). Here we find that ageing, known to negatively impact immune responses, impairs ACD in murine CD8(+) T cells, and that this phenotype can be rescued by transient mTOR inhibition. Increased ACD rates in mitotic cells from aged mice restore the expansion and memory potential of their cellular progenies. Further characterization of the composition of CD8(+) T cells reveals that virtual memory cells (T(VM) cells), which accumulate during ageing, have a unique proliferation and metabolic profile, and retain their ability to divide asymmetrically, which correlates with increased memory potential. The opposite is observed for naive CD8(+) T cells from aged mice. Our data provide evidence on how ACD modulation contributes to long-term survival and function of T cells during ageing, offering new insights into how the immune system adapts to ageing. |
| Keywords: | Adaptive Immunity, Immunological Memory, Lymphocyte Differentiation, T Cells, Animals, Mice |
| Source: | Nature Communications |
| ISSN: | 2041-1723 |
| Publisher: | Nature Publishing Group |
| Volume: | 12 |
| Number: | 1 |
| Page Range: | 2715 |
| Date: | 11 May 2021 |
| Official Publication: | https://doi.org/10.1038/s41467-021-22954-y |
| PubMed: | View item in PubMed |
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