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Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling

Item Type:Article
Title:Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling
Creators Name:Ericson, J. and Rashbass, P. and Schedl, A. and Morton, S. and Kawakami, A. and van Heyningen, V. and Jessell, T.M. and Briscoe, J.
Abstract:Distinct classes of motor neurons and ventral interneurons are generated by the graded signaling activity of Sonic hedgehog (Shh). Shh controls neuronal fate by establishing different progenitor cell populations in the ventral neural tube that are defined by the expression of Pax6 and Nkx2.2. Pax6 establishes distinct ventral progenitor cell populations and controls the identity of motor neurons and ventral interneurons, mediating graded Shh signaling in the ventral spinal cord and hindbrain.
Keywords:DNA-Binding Proteins, Embryonic Induction, Eye Proteins, Hedgehog Proteins, Homeodomain Proteins, Interneurons, Motor Neurons, Nervous System, Neurons, Organ Culture Techniques, Paired Box Transcription Factors, Proteins, Repressor Proteins, Rhombencephalon, Signal Transduction, Spinal Cord, Stem Cells, Trans-Activators, Transcription Factors, Animals, Chick Embryo
Source:Cell
ISSN:0092-8674
Publisher:Cell Press (U.S.A.)
Volume:90
Number:1
Page Range:169-180
Date:11 July 1997
Official Publication:https://doi.org/10.1016/S0092-8674(00)80323-2
PubMed:View item in PubMed

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