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Adolescence is a sensitive period for prefrontal microglia to act on cognitive development

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Item Type:Article
Title:Adolescence is a sensitive period for prefrontal microglia to act on cognitive development
Creators Name:Schalbetter, S.M., von Arx, A.S., Cruz-Ochoa, N., Dawson, K., Ivanov, A., Mueller, F.S., Lin, H.Y., Amport, R., Mildenberger, W., Mattei, D., Beule, D., Földy, C., Greter, M., Notter, T. and Meyer, U.
Abstract:The prefrontal cortex (PFC) is a cortical brain region that regulates various cognitive functions. One distinctive feature of the PFC is its protracted adolescent maturation, which is necessary for acquiring mature cognitive abilities in adulthood. Here, we show that microglia, the brain's resident immune cells, contribute to this maturational process. We find that transient and cell-specific deficiency of prefrontal microglia in adolescence is sufficient to induce an adult emergence of PFC-associated impairments in cognitive functions, dendritic complexity, and synaptic structures. While prefrontal microglia deficiency in adolescence also altered the excitatory-inhibitory balance in adult prefrontal circuits, there were no cognitive sequelae when prefrontal microglia were depleted in adulthood. Thus, our findings identify adolescence as a sensitive period for prefrontal microglia to act on cognitive development.
Keywords:Animals, Mice
Source:Science Advances
ISSN:2375-2548
Publisher:American Association for the Advancement of Science
Volume:8
Number:9
Page Range:eabi6672
Date:4 March 2022
Official Publication:https://doi.org/10.1126/sciadv.abi6672
PubMed:View item in PubMed

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