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RNA-based recognition and targeting: sowing the seeds of specificity

Item Type:Review
Title:RNA-based recognition and targeting: sowing the seeds of specificity
Creators Name:Gorski, S.A. and Vogel, J. and Doudna, J.A.
Abstract:RNA is involved in the regulation of multiple cellular processes, often by forming sequence-specific base pairs with cellular RNA or DNA targets that must be identified among the large number of nucleic acids in a cell. Several RNA-based regulatory systems in eukaryotes, bacteria and archaea, including microRNAs (miRNAs), small interfering RNAs (siRNAs), CRISPR RNAs (crRNAs) and small RNAs (sRNAs) that are dependent on the RNA chaperone protein Hfq, achieve specificity using similar strategies. Central to their function is the presentation of short 'seed sequences' within a ribonucleoprotein complex to facilitate the search for and recognition of targets.
Keywords:Bacteria, CRISPR-Cas Systems, Gene Expression Regulation, Gene Silencing, MicroRNAs, Small Interfering RNA
Source:Nature Reviews Molecular Cell Biology
Publisher:Nature Publishing Group
Page Range:215-228
Date:April 2017
Official Publication:https://doi.org/10.1038/nrm.2016.174
PubMed:View item in PubMed

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