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Salt, aldosterone, and the renin-angiotensin system in pregnancy

Item Type:Book Section
Title:Salt, aldosterone, and the renin-angiotensin system in pregnancy
Creators Name:Dechend, R. and Lamarca, B. and Davidge, S.T.
Abstract:This chapter reviews physiological changes in volume and osmolality in normal pregnancy, as well as alterations in volume associated with preeclampsia. There is a marked stimulation of the renin–angiotensin–aldosterone (RAA) system and a rise in the plasma concentration during normal pregnancy. In contrast, plasma volume and components of the RAA system decreased preeclampsia. Importantly, activating autoantibodies to the angiotensin II type I receptor (AT1-AA) are present in preeclampsia. There is an evolving literature on the role of inflammatory cells and cytokines in contributing to preeclampsia by leading to production of the AT1-AA, which is discussed in this chapter.
Keywords:Interstitial Volume, Preeclampsia, Pregnancy, Pressure Natriuresis, Renin-Angiotensin-Aldosterone System
Title of Book:Chesley's Hypertensive Disorders in Pregnancy
Publisher:Elsevier / Academic Press
Page Range:335-353
Official Publication:https://doi.org/10.1016/b978-0-12-818417-2.00010-5

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