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| Item Type: | Article |
|---|---|
| Title: | SARS-CoV-2 Beta variant infection elicits potent lineage-specific and cross-reactive antibodies |
| Creators Name: | Reincke, S.M. and Yuan, M. and Kornau, H.C. and Corman, V.M. and van Hoof, S. and Sánchez-Sendin, E. and Ramberger, M. and Yu, W. and Hua, Y. and Tien, H. and Schmidt, M.L. and Schwarz, T. and Jeworowski, L.M. and Brandl, S.E. and Rasmussen, H.F. and Homeyer, M.A. and Stöffler, L. and Barner, M. and Kunkel, D. and Huo, S. and Horler, J. and von Wardenburg, N. and Kroidl, I. and Eser, T.M. and Wieser, A. and Geldmacher, C. and Hoelscher, M. and Gänzer, H. and Weiss, G. and Schmitz, D. and Drosten, C. and Prüss, H. and Wilson, I.A. and Kreye, J. |
| Abstract: | SARS-CoV-2 Beta variant of concern (VOC) resists neutralization by major classes of antibodies from COVID-19 patients and vaccinated individuals. Here, serum of Beta-infected patients revealed reduced cross-neutralization of wildtype virus. From these patients, we isolated Beta-specific and cross-reactive receptor-binding domain (RBD) antibodies. The Beta-specificity results from recruitment of VOC-specific clonotypes and accommodation of mutations present in Beta and Omicron into a major antibody class that is normally sensitive to these mutations. The Beta-elicited cross-reactive antibodies share genetic and structural features with wildtype-elicited antibodies, including a public VH1-58 clonotype targeting the RBD ridge. These findings advance our understanding of the antibody response to SARS-CoV-2 shaped by antigenic drift with implications for design of next-generation vaccines and therapeutics. |
| Keywords: | Neutralizing Antibodies, Viral Antibodies, Antigenic Drift and Shift, COVID-19, Cross Reactions, Neutralization Tests, Protein Binding, Protein Domains, Protein Interaction Domains and Motifs, SARS-CoV-2, Coronavirus Spike Glycoprotein, Coronavirus Spike Coronavirus / Metabolism |
| Source: | Science |
| ISSN: | 0036-8075 |
| Publisher: | American Association for the Advancement of Science |
| Volume: | 375 |
| Number: | 6582 |
| Page Range: | 782-787 |
| Date: | 18 February 2022 |
| Official Publication: | https://doi.org/10.1126/science.abm5835 |
| PubMed: | View item in PubMed |
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