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Ten years of collaborative progress in the quest for orthologs

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Item Type:Review
Title:Ten years of collaborative progress in the quest for orthologs
Creators Name:Linard, B. and Ebersberger, I. and McGlynn, S.E. and Glover, N. and Mochizuki, T. and Patricio, M. and Lecompte, O. and Nevers, Y. and Thomas, P.D. and Gabaldón, T. and Sonnhammer, E. and Dessimoz, C. and Uchiyama, I.
Abstract:Accurate determination of the evolutionary relationships between genes is a foundational challenge in biology. Homology—evolutionary relatedness—is in many cases readily determined based on sequence similarity analysis. By contrast, whether or not two genes directly descended from a common ancestor by a speciation event (orthologs) or duplication event (paralogs) is more challenging, yet provides critical information on the history of a gene. Since 2009, this task has been the focus of the Quest for Orthologs (QFO) Consortium. The sixth QFO meeting took place in Okazaki, Japan in conjunction with the 67th National Institute for Basic Biology conference. Here, we report recent advances, applications, and oncoming challenges that were discussed during the conference. Steady progress has been made toward standardization and scalability of new and existing tools. A feature of the conference was the presentation of a panel of accessible tools for phylogenetic profiling and several developments to bring orthology beyond the gene unit—from domains to networks. This meeting brought into light several challenges to come: leveraging orthology computations to get the most of the incoming avalanche of genomic data, integrating orthology from domain to biological network levels, building better gene models, and adapting orthology approaches to the broad evolutionary and genomic diversity recognized in different forms of life and viruses.
Keywords:Orthology, Viruses, Phylogenetic Profiling, Paralogy, Xenology, Gene Models
Source:Molecular Biology and Evolution
Publisher:Oxford University Press
Page Range:3033-3045
Date:August 2021
Additional Information:Sofia Forslund is a member of the Quest for Orthologs (QFO) Consortium.
Official Publication:https://doi.org/10.1093/molbev/msab098
PubMed:View item in PubMed

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