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Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud

Item Type:Article
Title:Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud
Creators Name:Bladt, F. and Riethmacher, D. and Isenmann, S. and Aguzzi, A. and Birchmeier, C.
Abstract:Limb muscles develop from cells that migrate from the somites. The signal that induces migration of myogenic precursor cells to the limb emanates from the mesenchyme of the limb bud. Here we report that the c-met-encoded receptor tyrosine kinase is essential for migration of myogenic precursor cells into the limb anlage and for migration into diaphragm and tip of tongue. In c-met homozygous mutant (-/-) mouse embryos, the limb bud and diaphragm are not colonized by myogenic precursor cells and, as a consequence, skeletal muscles of the limb and diaphragm do not form. In contrast, development of the axial skeletal muscles proceeds in the absence of c-met signalling. The specific ligand of the c-met protein, the motility and growth factor scatter factor/hepatocyte growth factor, is expressed in limb mesenchyme and can thus provide the signal for migration which is received by c-met. We have therefore identified a paracrine signalling system that regulates migration of myogenic precursor cells.
Keywords:Cell Movement, Chimera, Diaphragm, Extremities, Hepatocyte Growth Factor, Mesoderm, Muscles, Mutagenesis, Proto-Oncogene Proteins c-Met, Receptor Protein-Tyrosine Kinases, Signal Transduction, Skeletal Muscle, Stem Cells, Tongue, Animals, Mice
Source:Nature
ISSN:0028-0836
Publisher:Nature Publishing Group (U.K.)
Volume:376
Number:6543
Page Range:768-771
Date:31 August 1995
Official Publication:https://doi.org/10.1038/376768a0
PubMed:View item in PubMed

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