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SPFH protein cage - one ring to rule them all

Item Type:Editorial
Title:SPFH protein cage - one ring to rule them all
Creators Name:Daumke, O. and Lewin, G.R.
Abstract:Stomatin/prohibitin/flotillin/HflKC (SPFH) proteins comprise a universally conserved family of membrane-associated scaffolds that compartmentalize membranes, but the detailed molecular mechanism has remained unclear. In a recent paper published in Cell Research, Ma et al. determined the cryo-EM structure of the bacterial SPFH heterodimer HflK/C, which assembles into a giant molecular cage encasing four AAA+ protease hexamers; the structural work elucidates how SPFH proteins confine their client proteins in specialized membrane microdomains.
Source:Cell Research
Publisher:Nature Publishing Group
Date:21 December 2021
Official Publication:https://doi.org/10.1038/s41422-021-00605-7
PubMed:View item in PubMed

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