SPFH protein cage - one ring to rule them all

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Item Type:	Editorial
Title:	SPFH protein cage - one ring to rule them all
Creators Name:	Daumke, O. and Lewin, G.R.
Abstract:	Stomatin/prohibitin/flotillin/HflKC (SPFH) proteins comprise a universally conserved family of membrane-associated scaffolds that compartmentalize membranes, but the detailed molecular mechanism has remained unclear. In a recent paper published in Cell Research, Ma et al. determined the cryo-EM structure of the bacterial SPFH heterodimer HflK/C, which assembles into a giant molecular cage encasing four AAA+ protease hexamers; the structural work elucidates how SPFH proteins confine their client proteins in specialized membrane microdomains.
Keywords:	Amino Acid Sequence, Membrane Proteins
Source:	Cell Research
ISSN:	1001-0602
Publisher:	Nature Publishing Group
Volume:	32
Number:	2
Page Range:	117-118
Date:	February 2022
Additional Information:	Copyright © 2021, Center for Excellence in Molecular Cell Science, CAS
Official Publication:	https://doi.org/10.1038/s41422-021-00605-7
PubMed:	View item in PubMed

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