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Vascular tissue specific miRNA profiles reveal novel correlations with risk factors in coronary artery disease

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Item Type:Article
Title:Vascular tissue specific miRNA profiles reveal novel correlations with risk factors in coronary artery disease
Creators Name:Neiburga, K. and Vilne, B. and Bauer, S. and Bongiovanni, D. and Ziegler, T. and Lachmann, M. and Wengert, S. and Hawe, J. and Güldener, U. and Westerlund, A. and Li, L. and Pang, S. and Yang, C. and Saar, K. and Huebner, N. and Maegdefessel, L. and Lange, R. and Krane, M. and Schunkert, H. and von Scheidt, M.
Abstract:Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide. Non-coding RNAs have already been linked to CVD development and progression. While microRNAs (miRs) have been well studied in blood samples, there is little data on tissue-specific miRs in cardiovascular relevant tissues and their relation to cardiovascular risk factors. Tissue-specific miRs derived from Arteria mammaria interna (IMA) from 192 coronary artery disease (CAD) patients undergoing coronary artery bypass grafting (CABG) were analyzed. The aims of the study were 1) to establish a reference atlas which can be utilized for identification of novel diagnostic biomarkers and potential therapeutic targets, and 2) to relate these miRs to cardiovascular risk factors. Overall, 393 individual miRs showed sufficient expression levels and passed quality control for further analysis. We identified 17 miRs–miR-10b-3p, miR-10-5p, miR-17-3p, miR-21-5p, miR-151a-5p, miR-181a-5p, miR-185-5p, miR-194-5p, miR-199a-3p, miR-199b-3p, miR-212-3p, miR-363-3p, miR-548d-5p, miR-744-5p, miR-3117-3p, miR-5683 and miR-5701–significantly correlated with cardiovascular risk factors (correlation coefficient >0.2 in both directions, p-value (p < 0.006, false discovery rate (FDR) <0.05). Of particular interest, miR-5701 was positively correlated with hypertension, hypercholesterolemia, and diabetes. In addition, we found that miR-629-5p and miR-98-5p were significantly correlated with acute myocardial infarction. We provide a first atlas of miR profiles in IMA samples from CAD patients. In perspective, these miRs might play an important role in improved risk assessment, mechanistic disease understanding and local therapy of CAD.
Keywords:Arteria Mammaria Interna, Biomarker, Biosensor, Coronary Artery Disease, Coronary Artery Bypass Grafting, Cardiovascular Disease, Local Therapy, Micro RNA, Personalized Medicine
Page Range:1683
Date:12 November 2021
Official Publication:https://doi.org/10.3390/biom11111683
PubMed:View item in PubMed

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