Dynamic and equilibrium properties of finite-size polymer models of chromosome folding

Item Type:	Article
Title:	Dynamic and equilibrium properties of finite-size polymer models of chromosome folding
Creators Name:	Conte, M. and Fiorillo, L. and Annunziatella, C. and Esposito, A. and Musella, F. and Abraham, A. and Bianco, S. and Chiariello, A.M.
Abstract:	Novel technologies are revealing that chromosomes have a complex three-dimensional organization within the cell nucleus that serves functional purposes. Models from polymer physics have been developed to quantitively understand the molecular principles controlling their structure and folding mechanisms. Here, by using massive molecular-dynamics simulations we show that classical scaling laws combined with finite-size effects of a simple polymer model can effectively explain the scaling behavior that chromatin exhibits at the topologically associating domains level, as revealed by experimental observations. Model results are then validated against recently published high-resolution in situ Hi-C data.
Keywords:	Genomics, Chromatin, Langevin Equation, Molecular Dynamics, Biological Physics
Source:	Physical Review E
ISSN:	2470-0045
Publisher:	American Physical Society
Volume:	104
Number:	5
Page Range:	054402
Date:	10 November 2021
Official Publication:	https://doi.org/10.1103/physreve.104.054402
PubMed:	View item in PubMed

Repository Staff Only: item control page