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Optical coherence tomography in multiple sclerosis: a 3-year prospective multicenter study

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Item Type:Article
Title:Optical coherence tomography in multiple sclerosis: a 3-year prospective multicenter study
Creators Name:Paul, F. and Calabresi, P.A. and Barkhof, F. and Green, A.J. and Kardon, R. and Sastre-Garriga, J. and Schippling, S. and Vermersch, P. and Saidha, S. and Gerendas, B.S. and Schmidt-Erfurth, U. and Agoropoulou, C. and Zhang, Y. and Seifer, G. and Petzold, A.
Abstract:OBJECTIVE: To evaluate changes over 3 years in the thickness of inner retinal layers including the peripapillary retinal nerve fiber layer (pRNFL), and combined macular ganglion cell and inner plexiform layers (mGCIPL), in individuals with relapsing-remitting multiple sclerosis (RRMS) versus healthy controls; to determine whether optical coherence tomography (OCT) is sufficiently sensitive and reproducible to detect small degrees of neuroaxonal loss over time that correlate with changes in brain volume and disability progression as measured by the Expanded Disability Status Scale (EDSS). METHODS: Individuals with RRMS from 28 centers (n = 333) were matched with 64 healthy participants. OCT scans were performed on Heidelberg Spectralis machines (at baseline; 1 month; 6 months; 6-monthly thereafter). RESULTS: OCT measurements were highly reproducible between baseline and 1 month (intraclass correlation coefficient >0.98). Significant inner retinal layer thinning was observed in individuals with multiple sclerosis (MS) compared with controls regardless of previous MS-associated optic neuritis--group differences (95% CI) over 3 years: pRNFL: -1.86 (-2.54, -1.17) µm; mGCIPL: -2.03 (-2.78, -1.28) µm (both p < 0.0001; effect sizes 0.39 and 0.34). Greater inner retinal layer atrophy was observed in individuals diagnosed with RRMS <3 years versus >5 years (pRNFL: p < 0.05; mGCIPL: p < 0.01). Brain volume decreased by 1.3% in individuals with MS over 3 years compared to 0.5% in control subjects (effect size 0.76). mGCIPL atrophy correlated with brain atrophy (p < 0.0001). There was no correlation of OCT data with disability progression. INTERPRETATION: OCT has potential to estimate rates of neurodegeneration in the retina and brain. The effect size for OCT, smaller than for magnetic resonance imaging based on Heidelberg Spectralis data acquired in this study, was increased in early disease.
Keywords:Atrophy, Brain, Optical Coherence Tomography, Prospective Studies, Relapsing-Remitting Multiple Sclerosis, Retina
Source:Annals of Clinical and Translational Neurology
Page Range:2235-2251
Date:14 December 2021
Official Publication:https://doi.org/10.1002/acn3.51473
PubMed:View item in PubMed

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