Helmholtz Gemeinschaft

Search
Browse
Statistics
Feeds

Challenges in cell transplantation for muscular dystrophy

Item Type:Article
Title:Challenges in cell transplantation for muscular dystrophy
Creators Name:Galli, F. and Mouly, V. and Butler-Browne, G. and Cossu, G.
Abstract:For decades now, cell transplantation has been considered a possible therapeutic strategy for muscular dystrophy, but failures have largely outnumbered success or at least encouraging outcomes. In this review we will briefly recall the history of cell transplantation, discuss the peculiar features of skeletal muscle, and dystrophic skeletal muscle in particular, that make the procedure complicated and inefficient. As there are many recent and exhaustive reviews on the various myogenic cell types that have been or will be transplanted, we will only briefly describe them and refer the reader to these reviews. Finally, we will discuss possible strategies to overcome the hurdles that prevent biological efficacy and hence clinical success.
Keywords:Cell Transplantation, Muscular Dystrophies, Myogenic Progenitor Cells, Clinical Trials, Animals
Source:Experimental Cell Research
ISSN:0014-4827
Publisher:Elsevier
Volume:409
Number:1
Page Range:112908
Date:1 December 2021
Official Publication:https://doi.org/10.1016/j.yexcr.2021.112908
PubMed:View item in PubMed

Repository Staff Only: item control page

Open Access
MDC Library