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Challenges in cell transplantation for muscular dystrophy

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Item Type:Article
Title:Challenges in cell transplantation for muscular dystrophy
Creators Name:Galli, F. and Mouly, V. and Butler-Browne, G. and Cossu, G.
Abstract:For decades now, cell transplantation has been considered a possible therapeutic strategy for muscular dystrophy, but failures have largely outnumbered success or at least encouraging outcomes. In this review we will briefly recall the history of cell transplantation, discuss the peculiar features of skeletal muscle, and dystrophic skeletal muscle in particular, that make the procedure complicated and inefficient. As there are many recent and exhaustive reviews on the various myogenic cell types that have been or will be transplanted, we will only briefly describe them and refer the reader to these reviews. Finally, we will discuss possible strategies to overcome the hurdles that prevent biological efficacy and hence clinical success.
Keywords:Cell Transplantation, Muscular Dystrophies, Myogenic Progenitor Cells, Clinical Trials, Animals
Source:Experimental Cell Research
Page Range:112908
Date:1 December 2021
Additional Information:Copyright © 2021. Published by Elsevier Inc. This manuscript version is made available under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/ or send a letter to Creative Commons, PO Box 1866, Mountain View, CA 94042, USA.
Official Publication:https://doi.org/10.1016/j.yexcr.2021.112908
PubMed:View item in PubMed

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