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Reduced mitochondrial respiration in T cells of patients with major depressive disorder

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Item Type:Article
Title:Reduced mitochondrial respiration in T cells of patients with major depressive disorder
Creators Name:Gamradt, S. and Hasselmann, H. and Taenzer, A. and Brasanac, J. and Stiglbauer, V. and Sattler, A. and Sajitz-Hermstein, M. and Kierszniowska, S. and Ramien, C. and Nowacki, J. and Mascarell-Maricic, L. and Wingenfeld, K. and Piber, D. and Ströhle, A. and Kotsch, K. and Paul, F. and Otte, C. and Gold, S.M.
Abstract:Converging evidence indicates that major depressive disorder (MDD) and metabolic disorders might be mediated by shared (patho)biological pathways. However, the converging cellular and molecular signatures remain unknown. Here, we investigated metabolic dysfunction on a systemic, cellular, and molecular level in unmedicated patients with MDD compared with matched healthy controls (HC). Despite comparable BMI scores and absence of cardiometabolic disease, patients with MDD presented with significant dyslipidemia. On a cellular level, T cells obtained from patients with MDD exhibited reduced respiratory and glycolytic capacity. Gene expression analysis revealed increased carnitine palmitoyltransferase IA (CPT1a) levels in T cells, the rate-limiting enzyme for mitochondrial long-chain fatty acid oxidation. Together, our results indicate metabolic dysfunction in unmedicated, non-overweight patients with MDD on a systemic, cellular, and molecular level. This evidence for reduced mitochondrial respiration in T cells of patients with MDD provides translation of previous animal studies regarding a putative role of altered immunometabolism in depression pathobiology.
Publisher:Cell Press
Page Range:103312
Date:19 November 2021
Official Publication:https://doi.org/10.1016/j.isci.2021.103312
PubMed:View item in PubMed

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