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| Item Type: | Article |
|---|---|
| Title: | Hemophagocytic lymphohistiocytosis and thrombotic microangiopathy after parvovirus B19 infection and renal transplantation: a case report |
| Creators Name: | Steffen, C.J. and Koch, N. and Eckardt, K.U. and Amann, K. and Seelow, E. and Schreiber, A. |
| Abstract: | BACKGROUND: Hemophagocytic lymphohistiocytosis (HLH) is a rare and life-threatening disease characterized by hyperactivation of the immune system that causes hypercytokinemia and potentially multi organ failure. HLH can occur in patients with underlying rheumatic or autoinflammatory disorders. Additionally, HLH can develop in patients during infections or malignancies without a known genetic predisposition. CASE PRESENTATION: We herein report a patient, who presented with fever, both acute kidney and liver injury, anemia, thrombocytopenia and HSV stomatitis. HLH was diagnosed based on clinical criteria and qPCR revealed an acute parvovirus B19 infection as potential underlying infectious trigger. Treatment was started with both IVIG and dexamethasone. Subsequently, kidney biopsy demonstrated TMA. CONCLUSIONS: In rare cases both HLH and aHUS can occur simultaneously in a patient as a consequence of viral infections. Insights from this unusual case might help physicians understand this complex symptom constellation. |
| Keywords: | Hemophagocytic Lymphohistiocytosis (HLH), Atypical Hemorrhagic Uremic Syndrome (aHUS), Parvovirus B19, Case Report |
| Source: | BMC Nephrology |
| ISSN: | 1471-2369 |
| Publisher: | BioMed Central |
| Volume: | 22 |
| Number: | 1 |
| Page Range: | 337 |
| Date: | 12 October 2021 |
| Official Publication: | https://doi.org/10.1186/s12882-021-02538-0 |
| PubMed: | View item in PubMed |
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