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Characteristics of secondary progressive multiple sclerosis: disease activity and provision of care in Germany - a registry-based/multicentric cohort study

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Item Type:Article
Title:Characteristics of secondary progressive multiple sclerosis: disease activity and provision of care in Germany - a registry-based/multicentric cohort study
Creators Name:Frahm, N., Ellenberger, D., Fneish, F., Christoph, K., Warnke, C., Zettl, U.K., Paul, F., Rauser, B., Stahmann, A., Vogelmann, V. and Flachenecker, P.
Abstract:BACKGROUND: The tailored immunomodulatory treatment strategy for secondary progressive multiple sclerosis (SPMS) depends on disease activity. OBJECTIVE: To assess the real-world situation in monitoring disease activity in SPMS patients and to identify associations of resulting subgroups with demographics, symptomatology, and therapy METHODS: This study included 4,263 SPMS patients from the German MS register (GMSR). For the classification into 'active' and 'inactive' according to relapse activity and MRI findings during the year prior to the latest clinical visit, we used the following definitions: active - gadolinium enhancing (Gd+)/new T2 lesions or ≥1 relapse, inactive - neither Gd+/new T2 lesions nor relapses. The active, inactive, and unclassifiable patients were compared in terms of clinical data, socio-demographics, symptomatology, healthcare, and DMT. RESULTS: Classification was possible for 1,513 (35.5%) SPMS patients, with 467 classified as active and 1,046 as inactive. For the classification, MRI data was available for 33.2% of the 4,263 patients. Higher MRI frequencies were observed for younger patients (OR 1.22 [1.12,1.33] per 10 years) with short disease duration (OR 1.19 [1.09, 1.30] per 10 years) (p < 0.001). CONCLUSION: MRI coverage was low, especially in elderly SPMS patients. Roughly one third of the SPMS patients presented markers of disease activity in the last year. Overall, the clinical differences (concerning symptomatology and care) between patients with active and inactive SPMS were small.
Keywords:Multiple Sclerosis, Secondary Progressive, Disease Course, Care, Disease Activity, Classification
Source:Multiple Sclerosis and Related Disorders
ISSN:2211-0348
Publisher:Elsevier
Volume:56
Page Range:103281
Date:November 2021
Official Publication:https://doi.org/10.1016/j.msard.2021.103281
PubMed:View item in PubMed

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